Mythbusting Supplements in Longevity Medicine (Part 1) - Bartley Clinic

Mythbusting Supplements in Longevity Medicine (Part 1)

We all have the desire to age gracefully, to keep our bodies and minds vibrant as the years go by, and supplements are frequently touted as potential tools to slow down ageing. In this 4-part series, let's take a closer look at common supplements and debunk some myths!

NAD/NMN: Cellular Fuel for Longevity

Nicotinamide adenine dinucleotide (NAD) and its precursor, nicotinamide mononucleotide (NMN), are like the cellular energy powerhouses that fuel our bodies. As we age, NAD levels decline, affecting our energy, metabolism, and overall health. Supplements like NMN claim to boost these levels.

However, there is no concrete evidence to support the claim that NAD supplementation directly results in anti-ageing effects or a longer lifespan. Research is ongoing, but claims of reversing ageing are currently unsubstantiated.

Instead of splashing out on NAD supplements, you can naturally increase NAD levels through dietary choices. Foods rich in NAD precursors, such as fish, chicken, and dairy products, can contribute to higher NAD levels. So, while NAD/NMN supplements may provide a convenient boost, there are natural ways to nurture your cellular vitality.

Spermidine: The Cellular Rejuvenator

Spermidine is a relatively less-known supplement that plays a crucial role in promoting cellular rejuvenation. It supports a process called autophagy, which can be thought of as cellular housekeeping. Autophagy helps your cells dispose of damaged components, making way for fresh, healthy ones. Spermidine, by facilitating autophagy, is believed to promote longevity and overall well-being.

Interestingly, spermidine isn't confined to supplement capsules. You can find it naturally in various foods. Wheat germ, soybeans, and mushrooms are rich sources of spermidine, making it accessible through a balanced diet. This means you can harness its potential without solely relying on supplements, which is a notable advantage in your quest for longevity.

Rapamycin: The mTOR Regulator

Rapamycin is an intriguing supplement that works by inhibiting the mTOR pathway. mTOR is involved in cell growth and metabolism, and controlling it may have profound effects on ageing. Current research conducted on mice has shown promise, while trials on humans are ongoing, but initial results suggest that rapamycin may extend lifespan and improve age-related health issues.

While rapamycin itself isn't found in everyday foods, your dietary choices can indirectly influence the mTOR pathway. Calorie restriction, for example, has been linked to mTOR regulation. By managing your calorie intake, you might be able to achieve some of the benefits associated with mTOR modulation.

Resveratrol: The Red Wine Elixir

Resveratrol, the compound found in red wine, has captured attention for its potential anti-ageing properties. It's known for its antioxidant effects, heart-protective qualities, and the possibility of enhancing longevity. Although research on resveratrol is ongoing, it's believed to activate specific genes associated with longer life.

Resveratrol isn't confined to wine bottles; it's also found in red grapes, peanuts, and other foods. While enjoying a glass of red wine in moderation may provide some resveratrol benefits, it's important to remember that it's not a magical elixir. Instead, it's part of a balanced diet that contributes to overall well-being.

These supplements certainly offer exciting potential in the realm of anti-ageing and longevity. However, they aren't a silver bullet. A holistic approach that includes a balanced diet, regular exercise, stress management, and other healthy lifestyle choices is vital to ageing gracefully and maintaining vibrant health. So, consider these supplements as companions on your journey towards a longer, healthier life, rather than quick fixes.


  1. “Nicotinamide mononucleotide (NMN) as an anti-ageing health product – Promises and safety concerns”
  2. “Effect of rapamycin on ageing and age-related diseases—past and future”
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